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How to change IssuerSigningKey after startup in asp.net core

hi,
I use this code at startup:

        services.AddAuthentication(JwtBearerDefaults.AuthenticationScheme)
            .AddJwtBearer(options =>
            {
                options.TokenValidationParameters = new TokenValidationParameters
                {
                    ValidateIssuerSigningKey = true,
                    IssuerSigningKey = new SymmetricSecurityKey(Encoding.UTF8
                        .GetBytes(Configuration.GetSection("AppSettings:Key").Value)),
                    ValidateIssuer = false,
                    ValidateAudience = false
                };
            });

and then I use Authorize Attribute to protect my controllers. is there any way to change the IssuerSigningKey later on after startup?

thanks