Securing gRPC-based Microservices in .NET Core

Dear andrea,
Great articles both Implementing Microservices with gRPC and .NET Core 3.1
and this one. You mentionned that both server and client “are meant to run on the server side, so both applications are not publicly accessible” (M2M scenario), therefore you are using Client Credentials Flow.

What about if the client and server are running on 2 separate computers?